Results: A 27-year-old male presented with a history of multiple infections since four months old, including recurrent episodes of acute otitis media, bronchitis, sinusitis and pneumonia, viral meningitis, mastoiditis, and cellulitis with abscesses of the axilla, thigh, and perianal region. Multivariable logistic regression was performed to determine infection risk based on C3 level while controlling for contributing factors. Among subjects with CTDs, we treated every C3 measurement as a single observation (n=1,197) and studied the association between C3 concentration and the 30-day odds of having a SBI.
Differences in rates of bacterial infection were assessed using the chi-square and kruskal-wallis tests when appropriate. Descriptive analyses were performed to determine medians and ranges for continuous variables. Infections requiring hospitalization or parenteral antibiotics were categorized as serious bacterial infections (SBIs). The date of birth, and date of lowest C3 level were considered as start points to calculate the observation periods for PCD and SCD subjects respectively. We recorded the number of infections, observation periods, diagnosis (PCD, SCD and its underlying etiology), lowest complement component levels, and the immunosuppressive agents used. Subjects with an undetectable complement activity (CH50) or any of the complement components measured at Seattle Childrens hospital from 2002-2018 were included in our study. Methods: We performed a retrospective cohort study. In 2017, she developed and was treated for another pneumonia. In 2015, she was placed on long-term immunoglobulin replacement therapy after being hospitalized for bilateral pneumonia for 5 nights requiring IV antibiotics for treatment. She recently (March 2017) had a splenectomy to remove her large spleen, and since then, her platelets have rebounded to 400-500K/UL. She received rituximab weekly for 4 weeks resulting in an increase of platelet count to 90-100K/UL.
In 2013 (30 years old), she had a severe nosebleed, for which she was admitted and treated with Amicar twice her platelets were found to be 2,000 K/UL. In 2012 (29 years old), she developed polyarthritis in her upper and lower extremities. When she was 15 years old, she remained thrombopenic and was started on high dose of immunoglobulin replacement therapy. Her bone marrow biopsy did not conclude myelokathesis. She was initially diagnosed with lupus and was given steroids. She was found to have Evans syndrome with idiopathic thrombocytopenic purpura (ITP), neutropenia, and lymphopenia. Our patient was healthy until she was 8 years old at that time, she developed joint pain, rash, and bruising. Therefore, it can be said that the extract has a positive effect on the blood system and plasma proteins and can increase the immune system without the presence of antigenic factors. According to the results, 100 and 200 mg/kg doses increased the amount of albumin, alpha-1 globulin, beta globulin, and A/G ratio. Obtained data were analyzed using the SPSS program (p<0.05). At the end of the experiment, blood samples were taken and used to measure blood proteins and their electrophoretic pattern. The extract was injected intraperitoneal every other day for 20 days. Mature female mice (Balb/C) were divided into 5 groups including control, placebo, and 50, 100, and 200mg/kg of extract. The current study was carried out to investigate the effects of adiantum hydroalcoholic extract on plasma proteins and electrophoretic pattern of blood in small laboratory mice. The Adiantum capillus a known medicinal herb in traditional medicine which is widely used in traditional medicine to deal with infection by having chemical compounds that affect the immune system.
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